function of RB protein

PROJECT Function of Rb Protein INTRODUCTION The retinoblastoma divisor (RB) is set on chromose 13 at position q14. It has 27 exons and is much than 200kilobases. Its mRNA codes for 928- aminic-acid-long polypeptide. Since it is convey in each(prenominal) booths, it is called a household gene. The harvest-feast of this gene is the retinoblastoma protein, which is actually a tumor suppressor protein. (6) Retinoblastoma protein, pRB, is a isobilateral heterodimer and it cannot consort unless the dimers are not together. So, the mutations that occur in the amino acids that integrate these dimers alter the protein power. (7) E2F is a gene family which is together with cognize as written text factors. There are many members of this family and all of them are involved in stall bi regular recurrence regulation, via ordinance a number of genes important in cell proliferation, and deoxyribonucleic acid synthesis. Their major role in cell cycle is providing the vicissitude from G1 to S-phase. (1,3-5,8,10,11) There are eight members of this family; E2F1-6 and DP1-2. They can function as transcriptional activators or repressors. Multiple E2Fs can bind to a cross gene asynchronously. (1,8,10) The expression of these members differ during cell proliferation response. cheek take aim of E2F1 increases at G1-S boundary.

E2F3 and E2F5 levels increases in early G1 and does nor mixture dramatically afterward that. E2F4 is expressed constitutively. Several E2F genes are shown to function as oncogenes in cancer development. (1) For example, E2F1, a member of E2F family, acts twain as an oncogen and a tumor suppressor! gene. It plays a multiple role, on the star hand by inducing S-promoting genes transcription and on the another(prenominal) by directly influencing apoptosis execution. (2,9) A touristed warning for how E2F family members regulate G1/S-phase-specific gene expression invokes a coordination compound variety of protein-protein and protein-DNA interactions that change as cells progress through the cell cycle. (10) Since E2F bottom genes show...If you want to get a full essay, coif it on our website: OrderCustomPaper.com

If you want to get a full essay, visit our page: write my paper